Weill Medical College of Cornell University

• Home
• Overview
• Education
• Fellowships
• Research
• Faculty

Human Papillomavirus (HPV):

Human Papillomavirus Test and Treat in HIV-Infected Women. Wilkin. Cervical cancer is a major cause of morbidity and mortality in areas of the world without access to cervical cancer screening. Implementation of cytology-based screening is difficult in areas with limited resources. This clinical trial will investigate a promising alternative screening strategy: a direct test for high-risk HPV types with immediate cryotherapy for those women with HPV detected. This project will be conducted at clinical trials sites in Africa, Peru, India and Haiti. This study will randomize women to a conventional cytology-based cervical cancer screening or a novel HPV test-and-treat strategy. This is funded in part by a PEPFAR/NIH collaboration.

Human Papillomavirus Vaccination in HIV-1-Infected Men. Wilkin. Anal carcinoma is increased among HIV+ and HIV- men who have sex with men. Similar to the cervix, premalignant lesions of the anus (squamous intraepithelial lesions or SIL) are readily detectable by screening cytology and have high-risk types of human papillomavirus as the most important cofactor. This study evaluated the safety and immunogenicity of the quadrivalent HPV vaccine in HIV-1-infected men. The study found that the vaccine was safe and highly immunogenic. An extension of the clinical trial will evaluate whether this vaccine induces immune memory. A follow-up clinical trial is being developed that will test the efficacy of this vaccine in this population.

• Wilkin Tz, Lee JY, Lensing SY, Stier EA, Goldstone SE, Berry JM, Jay N, Aboulafia D, Cohn DL, Einstein MH, Saah A, Mitsuyasu RT, Palefsky JM. Safety and immunogenicity of the quadrivalent human papillomavirus vaccine in HIV-1-infected men. J Infect Dis. 2010 Oct 15;202:1246-53.