Weill Medical College of Cornell University

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Brazil:

The collaboration between Cornell University and the Federal University of Bahia started in 1964 and may be the longest collaboration of its type in the world today. To date, over 20 Cornell faculty members and ~120 students and fellows have participated in the program, and over 250 peer reviewed journal publications have emerged from the research. The program has been funded by the Commonwealth Fund and the Rockefeller Foundation, and since 1979, by the NIH. The current NIH funding supports our Tropical Medicine Research Center and a research training program in infectious diseases in Salvador, Brazil.

Leishmaniasis and HTLV-I: Carvalho, Johnson, Glesby. This is a multi-disciplinary research program with investigators from Brazil and the United States. We seek to define the pathogenesis of these diseases and to develop intervention measures. Research is conducted at field study sites in the state of Bahia, Brazil, the Federal University of Bahia, and the Division of Infectious Diseases at Cornell. We are working to identify host and parasite factors that determine the outcome of leishmania infection. Based on the immunological studies previously performed, clinical trials have been performed using immunomodulatory agents combined with antimony therapy in cutaneous and mucosal leishmaniasis. Ongoing studies are also investigating the spectrum and natural history of subclinical and clinical disease in HTLV-I infection in relation to cytokine profiles and co-infections.

• Jirmanus L, Glesby MJ, Guimar�es LH, Lago E, Rosa ME, Machado PR, Carvalho EM. Epidemiological and clinical changes in American Tegumentary Leishmaniasis in an area of Leishmania (Viannia) Braziliensis transmission over a 20 year period. Am J Trop Med Hyg 2012; 86:426-33.
• Newlove T, Guimar�es LH, Morgan DJ, Alcantara L, Glesby MJ, Carvalho EM, Machado PR. Antihelminthic therapy and antimony in cutaneous leishmaniasis: a randomized, double-blind, placebo-controlled trial in patients co-infected with helminths and Leishmania braziliensis. Am J Trop Med Hyg 2011; 84:551-55.
• Poetker SKW, Porto AF, Giozza SP, Muniz AL, Caskey MF, Carvalho EMC, Glesby MJ. Clinical manifestations in individuals with recent diagnosis of HTLV type I infection. J Clin Virol 2011; 51:54-58.
• Sundberg MA, Costa D, Orge G, Castro NM, Muniz A, Glesby MJ, Carvalho EM. Helminthic infection and the risk of neurologic disease progression in HTLV-1. J Clin Virol 2012; 53:251-55.
• Unger A, O�Neal S, Machado PRL, Guimaraes LH, Morgan DJ, Schriefer A, Bacellar O, Glesby MJ, Carvalho EM. Association of treatment of American cutaneous leishmaniasis prior to ulcer development with high rate of failure in Northeastern Brazil. Am J Trop Med Hyg 2009; 80:574-79.