PANTHER Study (Prednisone, Azathioprine, and N-acetylcysteine: A Study That Evaluates Response in IPF)
Study Status
Closed to Enrollment
Study Description
The purpose of the PANTHER study is to evaluate the effectiveness of N-acetylcysteine (NAC) in preventing the loss of lung function in people with Idiopathic Pulmonary Fibrosis (IPF).
IPF is a disease in which fibrous tissue clogs and damages the air sacs within the lungs. Widespread and permanent scarring and stiffening of lung tissue eventually results. Individuals with IPF may experience breathing difficulties, cough, chest pain, and a decreased exercise capacity. Although the cause of IPF is not definitively known, it may be a result of an inflammatory response to an unknown substance. There is no cure for IPF, and no approved treatment for the disease. NAC, an antioxidant that is effective at loosening up mucus that forms in the lungs, may improve lung function. The purpose of this study is to evaluate the effectiveness of NAC at preventing the loss of lung function in people with IPF.
This study will enroll people with mild to moderate IPF. Study volunteers will be randomly assigned to receive, for 60 weeks, either:
- NAC
- or placebo (an inactive pill that has no treatment value, to use as a comparison)
Study visits will occur at baseline (study entry) and weeks 4, 15, 30, 45 and 60. Volunteers will be asked to record medication usage and symptoms in a daily diary.
Travel reimbursement: Volunteers will be reimbursed a maximum of $250 per visit for study travel expenses relating to mileage, commercial air or ground travel, hotel costs, meals and parking fees after providing travel receipts to the study coordinator.
Click here to visit our IPF blog.
Disease Status and/or Stage
Idiopathic Pulmonary Fibrosis (IPF)
Sponsor
IPFnet/NIH
Key Eligibility
- Men and women ages 35–85
- Diagnosed with Idiopathic Pulmonary Fibrosis (IPF) within the past 48 months (4 years)
- More detailed eligibility requirements will be discussed with you when contact the study team
Principal Investigator
Contact
- Ida Cao
- 646-962-4508
- [email protected]
Healthy Volunteers
As a healthy volunteer in a clinical trial you may make a significant contribution to the discovery of medical knowledge and new treatments that could impact people around the world.
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Contact Us
For general inquiries, or if you need assistance finding a study, please contact:
Robert Hagerty
Subject Recruitment Manager
Tel: (646) 962-9340
[email protected]
