Characterization of Intestinal Microbiota to Evaluate Kidney Allograft Status

Study Status

Open to Enrollment

Study Description

This is a prospective study to determine the association between bacteria in stool and the immune system of kidney transplant recipients. A process called acute rejection remains an important cause of kidney transplant failure. During rejection, the body’s immune system recognizes the kidney as foreign and damages the organ. The mechanism by which rejection happens is not well understood. Recent research suggests that the body’s immune system may be altered by intestinal bacteria. The purpose of this study is to characterize changes in bacterial composition in the intestinal tract that can predict and diagnose kidney transplant rejection.

Eligible subjects will be asked to provide fecal specimen before transplantation, after transplantation, and whenever the patient has kidney dysfunction. Fecal specimens will be obtained at time of routine laboratory work in the clinic or in the hospital.


Weill Cornell Clinical and Translational Science Center

Key Eligibility

  • Men and women age 18 and older
  • Will receive or have already received a kidney transplant

Principal Investigator

Thangamani Muthukumar, MD


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Contact Us

For general inquiries, or if you need assistance finding a study, please contact:

Robert Hagerty
Subject Recruitment Manager
Tel: (646) 962-9340
[email protected]

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