Treatment algorithm for resistant hypertension

Study Status

Open to Enrollment

Study Description

Resistant hypertension RH) is defined as hypertension that fails to come under control despite treatment with 3 antihypertensive drugs including a diuretic. Currently physicians add drug after drug, often without any rationale, with negative consequences including persisting blood pressure (BP) elevation, side effects, and excessive number of medications.

The purpose of this study is to assess the response to the systematic and simplified, and therefore very teachable, approach we use at the Hypertension Center, that limits treatment to a mere 2 options: 

(1) augmentation of the diuretic regimen, and/or

(2) addition of combined alpha/beta blockade

Both options employ drugs that are approved for treatment of hypertension, and at approved dosages. Our preliminary data indicate that RH can be controlled in 80-90% of such patients with this approach. We also intend to collect data on biochemical and psychological variables to determine if they are helpful in predicting which treatment option is more likely to be effective in the individual patient.

Sponsor

Hypertension Research Fund

Key Eligibility

  • Age 21-80
  • New patients to the Hypertension Center
  • Office BP > 140/90 despite treatment with 3 antihypertensive agents including a diuretic
  • Causes of secondary hypertension have been excluded by usual clinical criteria

Principal Investigator

Samuel Mann, MD

Contact

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Contact Us

For general inquiries, or if you need assistance finding a study, please contact:

Robert Hagerty
Subject Recruitment Manager
Tel: (646) 962-9340
[email protected]

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