Fludeoxyglucose F 18 PET Scan, CT Scan, and Ferumoxtran-10 MRI Scan Before Chemotherapy and Radiation Therapy in Finding Lymph Node Metastasis in Patients With Locally Advanced Cervical Cancer or High-Risk Endometrial Cancer

Study Status

Open to Enrollment

Study Description

This clinical trial is for women with locally advanced cervical or high-risk endometrial cancer. The purpose of the study is to determine if the FDG-PET/CT scan can find cancer that may have spread to the lymph nodes.

The FDG-PET/CT scan is a PET/Ct scan using an agent called FDG (Fluorodeoyglucose). The study will compare findings from the scan and surgery to determine which one is better at finding cancer that may have spread to the lymph nodes before participants undergo chemotherapy and radiation therapy.

Study participants will undergo lymphadenectomy (lymph node removal) with pelvic and abdominal lymph node biopsy within 2 weeks after the PET/CT scan. Participants diagnosed with metastatic disease prior to lymph node biopsy proceed directly to primary treatment. Participants with cervical cancer will undergo chemoradiotherapy within 4 weeks of PET/CT scan. After completion of study therapy, participants will be followed at 6 weeks, 6 months, every 3 months for 2 years, and then every 6 months for 3 years.

Disease Status and/or Stage

Locally Advanced Cervical Cancer or High-Risk Endometrial Cancer



Key Eligibility

  • Women age 18 and older
  • Diagnosed with either:
    • Cervical cancer, previously untreated, primary disease
      • Locally advanced Stage IB,IIA or IIB-IVA disease
    • High-risk endometrial cancer
  • No known metastases to other organs outside the pelvis or abdominal lymph nodes at the time of original diagnosis
  • Detailed eligibility reviewed when you contact the study team

Principal Investigator

Divya Gupta, M.D.


  • Dr. Gupta
  • (212) 746-3307

Healthy Volunteers


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Contact Us

For general inquiries, or if you need assistance finding a study, please contact:

Erica Bersin
Tel: (646) 962-8232
[email protected]

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