The BEACON Study (Breast Cancer Outcomes With NKTR-102)

Study Status

Open to Enrollment

Study Description

Full protocol title: The BEACON Study (Breast Cancer Outcomes with NKTR-102): A Phase 3 Open-Label, Randomized, Multicenter Study of NKTR-102 versus Treatment of Physician’s Choice (TPC) in Patients with Locally Recurrent or Metastatic Breast Cancer Previously Treated with an Anthracycline, a Taxane, and Capecitabine

This clinical trial is for women with locally recurrent or metastatic breast cancer that was previously treated with an anthracycline, a taxane, and capecitabine.

The purpose of the study is to test how well women with breast cancer respond to treatment with the experimental drug NKTR-102, compared to standard treatments for breast cancer. The study will also look at the side effects of the study drug and examine how long NKTR-102 stays in a patient’s blood.

Study participants will be randomly assigned to one of two study arms.

  • Arm A: participants will receive NKTR-102 via infusion on Day 1 of each 21 day cycle.
  • Arm B: participants will receive one of seven standard of care treatment options available at the study center. The choice of treatment in Arm B will be made after discussions with your doctor. Depending on which drug is chosen by you and your doctor, cycles in Arm B will be either 21 days or 28 days.

The study will take about 38 months to complete. The amount of time on study depends on how well a participant responds to study treatment. 

Disease Status and/or Stage

Locally Recurrent or Metastatic Breast Cancer Previously Treated with Cytotoxic Chemotherapy


Nektar Therapeutics

Key Eligibility

  • Women age 18 and older
  • Diagnosed with breast cancer
  • Locally recurrent or metastatic disease
  • Prior therapy must have included anthracycline, a taxane, and Xeloda; must have receiveda minimum of 2 and maximum of 5 prior cyotoxic chemotherapy regimens
  • Detailed eligibility reviewed when you contact the study team

Principal Investigator

Tessa Cigler, MD


  • Marta Cobham
  • (212) 821-0780
  • [email protected]
  • Weill Cornell Breast Center
  • (212) 821-0644

Healthy Volunteers


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Contact Us

For general inquiries, or if you need assistance finding a study, please contact:

Robert Hagerty
Subject Recruitment Manager
Tel: (646) 962-9340
[email protected]

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