A Phase II Study of Tetrathiomolybdate (TM) in patients with breast cancer at moderate to high risk of recurrence
Study Status
Open to Enrollment
Study Description
This study is for patients who have or have had breast cancer and have a moderate to high risk of the breast cancer coming back.
The study is trying to decrease levels of factors in patients’ blood that scientists believe are, at least in part, responsible for the new blood vessels that are created by tumors and that allow the tumors to grow and spread elsewhere in the body. When new blood vessels are formed, this process is called angiogenesis. Tumors that have higher levels of angiogenesis markers in the blood grow faster, and these patients have a higher chance of tumor coming back. If this process is interrupted, tumors may not be able to grow or spread.
This study attempts to interfere with angiogenesis by trying to deplete copper stores in the body using a pill called tetrathiomolybdate (TM). TM is not approved by the FDA in cancer patients, so its use in this study is experimental.
Patients will take TM 4 times daily during the Induction phase, and then 3 times daily during the maintenance phase. Treatment may continue for 2 years on the study. Selected patients may potentially continue TM for additional 2 years and up to 6 years if the physician believes it would benefit the patient.
Disease Status and/or Stage
High-Risk Stage II Breast Cancer; Stage III Breast Cancer; Stage IV Breast Cancer in Remission
Sponsor
Weill Cornell Medical College
Key Eligibility
- Age 18 or older
- Must have breast cancer that is:
- High-risk Stage II breast cancer
- Stage III breast cancer, including inflammatory breast cancer
- Stage IV breast cancer in complete remission
- Triple negative tumors
- Patients with Stage IV breast cancer or Multiple Positive Nodes may also be considered for participation. Please contact to confirm eligibility.
- Detailed eligibility reviewed when you contact the study team
Principal Investigator
Contact
- Marta Cobham
- (212) 821-0780
- [email protected]
Healthy Volunteers
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Contact Us
For general inquiries, or if you need assistance finding a study, please contact:
Erica Bersin
Tel: (646) 962-8232
[email protected]
