A Randomized Double-Blinded Phase III Study Comparing Gemcitabine, Cisplatin, and Bevacizumab to Gemcitabine, Cisplatin, and Placebo in Patients With Advanced Transitional Cell Carcinoma

Study Status

Open to Enrollment

Study Description

The purpose of this trial is to study gemcitabine hydrochloride, cisplatin, and bevacizumab to see how well they work compared with gemcitabine hydrochloride, cisplatin, and placebo in treating patients with advanced urinary tract cancer.

Drugs used in chemotherapy, such as gemcitabine hydrochloride and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether gemcitabine hydrochloride and cisplatin are more effective when given together with or without bevacizumab in treating patients with urinary tract cancer.

Disease Status and/or Stage

Advanced Transitional Cell Carcinoma

Sponsor

Cancer and Leukemia Group B (CALGB); National Cancer Institute (NCI)

Key Eligibility

  • Men and women, age 18 and older
  • Confirmed transitional cell carcinoma of the urinary tract (renal pelvis, ureter, bladder, prostate, or urethra)
  • Not a candidate for potentially curative surgery or radiotherapy
  • No history of periotoneal carcinomatosis (a type of secondary cancer that affects the lining of the abdominal cavity)
  • No known brain metastases
  • Additional entry criteria to be discussed when you contact the study team

Principal Investigator

Scott Tagawa, MD

Contact


Healthy Volunteers

healthy_volunteers.jpg

As a healthy volunteer in a clinical trial you may make a significant contribution to the discovery of medical knowledge and new treatments that could impact people around the world.
Click here for studies seeking healthy volunteers.

Contact Us

For general inquiries, or if you need assistance finding a study, please contact:

Erica Bersin
Tel: (646) 962-8232
[email protected]

Top of page