CALGB 140503: A Phase III Randomized Trial of Lobectomy versus Sublobar Resection for Small (<2cm) Peripheral Non-Small Cell Lung Cancer

Study Status

Open to Enrollment

Study Description

This randomized trial is studying different types of surgery to compare how well they work in treating patients with stage IA non-small cell lung cancer.

Sublobar resection (wedge resection or segmentectomy) may be less invasive types of surgery than lobectomy for non-small cell lung cancer and may have fewer side effects and improve recovery. It is not yet known whether wedge resection or segmentectomy are more effective than lobectomy in treating stage IA non-small cell lung cancer.

Patients will be randomized to receive a Lobectomy or a Sublobar Resection. After completion of study treatment, patients are followed up every 6 months for 2 years and then annually for 5 years.

Disease Status and/or Stage

Non-small Cell Lung Cancer


Cancer and Leukemia Group B, National Cancer Institute

Key Eligibility

  • Men and women age 18 and older
  • Suspected or proven non-small cell lung cancer
  • Peripheral lung nodule ≤ 2 cm on preoperative CT scan and presumed to be lung cancer
  • No prior malignancy within 5 years other than non-melanoma skin cancer, superficial bladder cancer, or CIS of the cervix
  • The tumor location must be suitable for either lobar or sublobar resection (wedge or segment)
  • Additional eligibility to be discussed when you contact the study team

Principal Investigator

Nasser Altorki, MD


  • Estella Hernandez, RN
  • 212-746-3328

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Contact Us

For general inquiries, or if you need assistance finding a study, please contact:

Robert Hagerty
Subject Recruitment Manager
Tel: (646) 962-9340
[email protected]

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