CALGB 10403: An Intergroup Phase II Clinical Trial for Adolescents and Young Adults With Untreated Acute Lymphoblastic Leukemia (ALL)

Study Status

Open to Enrollment

Study Description

Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. This phase II trial is studying how well combination chemotherapy works in treating young patients with newly diagnosed acute lymphoblastic leukemia.

The purpose of this study is to evaluate the effectiveness and side-effects of an intensive program using multiple chemotherapy drugs that has been designed for children but is now being used in young adults up to age 40. We hope to improve the outcome of adolescents and young adults with acute lymphoblastic leukemia (ALL).

We will compare the outcomes of subjects treated by adult hematologists and oncologists on this study with the outcomes of similar subjects treated with the same chemotherapy program by pediatric oncologists (doctors who specialize in the treatment of cancer in children).

Better results have been reported when 16-20 year old subjects with acute lymphoblastic leukemia (ALL) were treated in a pediatric clinic with a pediatric chemotherapy program. One of the important goals of this study is to deliver the treatment with as little delay or variation in treatment doses as possible. We are testing whether or not young adults have better outcomes if all of the prescribed therapy is given on time.

Disease Status and/or Stage

Newly Diagnosed Acute Lymphoblastic Leukemia (ALL)

Sponsor

CALGB; NCI; Eastern Cooperative Oncology Group; Southwest Oncology Group

Key Eligibility

  • Men and women age 16 to 40
  • Newly diagnosed B-precursor or T-precursor Acute Lymphoblastic Leukemia (ALL)
  • Detailed eligibility discussed when you contact the study team

Principal Investigator

Ellen Ritchie, MD

Contact

Protocol ID

CALGB 10403

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Contact Us

For general inquiries, or if you need assistance finding a study, please contact:

Robert Hagerty
Subject Recruitment Manager
Tel: (646) 962-9340
[email protected]

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