Use of PCR to Evaluate Renal Allograft Status (Diagnostic and Serial Biopsies)

Study Status

Open to Enrollment

Study Description

This is a prospective study of kidney or combined kidney/pancreas transplant recipients to examine potential biological markers (genes expressed in blood, urine and kidney tissue) of transplant kidney status that may be able to predict rejection.  Rejection is a process where the body’s immune cells attack the transplant kidney, which the body considers as foreign.  Doctors generally perform a biopsy (taking a small portion of the transplant kidney using a needle) to determine if there is rejection.

Under this research study, blood and urine will be collected during hospitalization, at the time of undergoing kidney biopsies, and periodically at clinic visits.  In addition, a portion of the tissue obtained during biopsy will be analyzed in our research laboratory.  
Tissue samples for this study will be obtained only when transplant recipients are undergoing kidney biopsies to determine the cause of transplant kidney dysfunction. Participants will not be asked to undergo biopsies for the sole purpose of this research study.


NIH; Qatar National Research Foundation (QNRF); Quest Diagnostics, Inc.

Key Eligibility

  • Men and women age 18-85 who have received a kidney transplant or combined kidney/pancreas tranplant
  • Must be able to provide informed consent

Principal Investigator

Manikkam Suthanthiran, MD


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Contact Us

For general inquiries, or if you need assistance finding a study, please contact:

Robert Hagerty
Subject Recruitment Manager
Tel: (646) 962-9340
[email protected]

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