An Open-Labeled, Multicenter Phase II Study of Cabazitaxel in Refractory Metastatic Gastric or Gastroesophageal Adenocarcinoma

Study Status

Open to Enrollment

Study Description

This clinical trial is for men and women with metastatic gastric or gastroesophageal (GEJ) cancer. 

The purpose of the study is to determine if the drug cabazitaxel is effective for the treatment of metastatic gastric or GEJ cancer. Cabazitaxel is a chemotherapy medication that helps stop cancer cells from growing and multiplying by interfering with certain structures in the cell. It is FDA-approved for treating prostate cancer but not for gastric cancer.

All participants in this study will receive cabazitaxel; there is no placebo. Study participants will be assigned to one of two study arms:

  • Arm A: participants who have never received taxane-based chemotherapy
  • Arm B: participants who have previously received taxane-based chemotherapy

Participants in both arms will receive cabazitaxel via infusion once every 3 weeks. The purpose of the arm assignment is to help the researchers analyze if there is a difference in the way different groups respond to the study drug. 

Study participants may continue treatment with cabazitaxel as long as they are responding to treatment and do not experience unacceptable side effects. 

Disease Status and/or Stage

Metastatic Gastric or Gastroesophageal (GEJ) Cancer


Weill Cornell Medical College

Key Eligibility

  • Men and women age 18 and older
  • Metastatic gastric or gastroesophageal (GEJ) cancer
  • Have had at least 1 prior cytotoxic chemotherapy regimen for metastatic disease; prior taxane therapy is allowed
  • Detailed eligibility reviewed when you contact the study team

Principal Investigator

Manish Shah, MD


Healthy Volunteers


As a healthy volunteer in a clinical trial you may make a significant contribution to the discovery of medical knowledge and new treatments that could impact people around the world.
Click here for studies seeking healthy volunteers.

Contact Us

For general inquiries, or if you need assistance finding a study, please contact:

Erica Bersin
Tel: (646) 962-8232
[email protected]

Top of page