CPX-351 as Salvage Chemotherapy Followed by a Reduced Intensity Conditioning (RIC) Stem Cell Transplantation Utilizing Double Umbilical Cord Blood (dUCB) Grafts for Patients with Relapsed or Refractory Leukemia

Study Status

Open to Enrollment

Study Description

This is a clinical trial for men and women with relapsed or refractory acute myeloid leukemia, acute lymphoid leukemia, chronic myeloid leukemia or myelodysplastic syndrome.

The purpose of this study is to determine how the experimental agent CPX-351 works in reducing the growth of leukemia cells prior to a double umbilical cord blood transplant.

CPX-351 is a formulation of a fixed combination of the antitumor drugs Cytarabine and Daunorubicin, contained in a fat droplet (liposome). It is possible that fixing the combination in a fat droplet is superior to administering Cytarabine and Daunorubicin individually in the treatment of acute leukemia. It is hoped that by providing CPX-351 prior to transplant, a reduction in leukemia cells will occur and will improve the chance for a successful engraftment of healthy stem cells from two umbilical cords.

Historically, umbilical stem cell transplant has not been as effective for people with resistant leukemia. Adding CPX-351 prior to transplant may have a beneficial effect on the outcome of a double umbilical cord transplant.

Disease Status and/or Stage

Relapsed/Refractory Leukemia


Weill Cornell Medical College

Key Eligibility

  • Men and women age 18 to 70
  • Diagnosis of:
    • Acute Myeloid Leukemia (AML)
    • Acute Lymphoid Leukemia (ALL)
    • Chronic Myeloid Leukemia (CML)
    • Myelodysplastic Syndrome (MDS)
  • Relapsed/refractory disease
  • No available matched related or unrelated adult stem cell grafts
  • Detailed eligibility reviewed when you contact the study team

Principal Investigator

Usama Gergis, MD


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Contact Us

For general inquiries, or if you need assistance finding a study, please contact:

Robert Hagerty
Subject Recruitment Manager
Tel: (646) 962-9340
[email protected]

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